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April 3, 2017

Online metabolic calculator better in determining risk of diseases

An online metabolic calculator developed by a University of Virginia School of Medicine doctor and his research partner at the University of Florida can predict people’s risk of developing heart disease and diabetes more accurately than traditional methods. That is the outcome of a large new UVA study.

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The UVA physician – Mark DeBoer  – hopes the new tool will prompt patients to make lifestyle changes that would spare them the suffering and expense of avoidable illnesses. “This boils it down to telling a patient, ‘On the risk spectrum, you are here, and you’re in a position where we’re worried you’re going to have a cardiovascular event in the next 10 years,’” says De Boer, MD, of the UVA School of Medicine and the UVA Children’s Hospital. “My hypothesis is that the more specific information you can give to individuals at risk, the more they will understand it and be motivated to make some changes.”

Black-and-white approach

Physicians traditionally have predicted risk for cardiovascular disease, type 2 diabetes and stroke by looking for five factors: obesity, high blood pressure, high fasting triglycerides, low HDL (good) cholesterol and high fasting blood sugar.  Patients with abnormalities in at least three of these are diagnosed as having metabolic syndrome and told that they are at elevated risk for future health problems.

The problem with that approach is that it is black-and-white. DeBoer: “As is true in most processes in life, the reality is that this risk exists on a spectrum,” he said. “Someone who has values in each of these individual risk factors that are just below the cutoff still has more risk for future disease than somebody who has very low values.”

The traditional approach also fails to consider variables like race, ethnicity and gender. For example,  African-American men are unlikely to be diagnosed with metabolic syndrome but still have a high risk for cardiovascular disease and type 2 diabetes.

Testing predictions

On the other hand, the ‘metabolic crystal ball,’ developed by DeBoer and Matthew Gurka, PhD, from the University of Florida, weights the traditional risk factors ánd takes into account race, gender and ethnicity, in order to produce an easy-to-understand metabolic severity score.

 A small study previously found that the online calculator’s predictions lined up well with actual cases of cardiovascular disease and diabetes, the large new study further confirms this.  The study looked, retroactively, at outcomes in more than 13,000 people and found that DeBoer and Gurka’s tool was a better risk predictor than the individual risk factors alone.

DeBoer believes this suggests that, when somebody has this congregation of metabolic syndrome findings, there probably is some underlying process that is producing those findings, and that those underlying processes are also contributing to future risk. “The hope is that a scoring system like this could be incorporated in the electronic medical record to calculate someone’s risk and that information could be provided both to the physician, who then realizes there is an elevated risk, and to the patient, who hopefully can start taking some preventative steps.”

Study findings
DeBoer and colleagues have described the study findings in the Journal of the American College of Cardiology. The research team consisted of DeBoer; Matthew J. Gurka, PhD; ?Sherita Hill Golden, MD; Solomon K. Musani, PhD; Mario Sims, PhD; ?Abhishek Vishnu, PhD?; Yi Guo, PhD; and ?Thomas A. Pearson, MD, PhD.

The tool is available as a free online calculator at http://mets.health-outcomes-policy.ufl.edu/calculator/. Further research is required to determine exact cut-off values of the score that indicate particular jumps in risk.  The score is primarily intended for physicians but can be used by anyone who has the needed health information.

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