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August 23, 2017

New method can selectively erase fear memory

Anyone remember the Total Recal movies, where Arnold Schwarzenegger and later Colin Farrell -have memories implanted that erase their former identities? Sounds like Science Fiction right? But researchers at the University of California, Riverside, are working on making it a Science Fact. They have developed a method to selectively erase particular fear memories by weakening the connections between the nerve cells (neurons) involved in forming these memories.

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Fear memories are often formed when a sight, sound, or smell stimulus is associated with a traumatic event, such as a car accident. Fearful responses are then triggered by the stimulus. These responses can often help out in response to dangerous situations, for both animals and humans. But not all fear memories, such as those in PTSD, are beneficial to our survival. For example, while an extremely fearful response to the sight of a helicopter is not a useful one for a war veteran, a quick reaction to the sound of a gunshot is still desirable. For survivors of car accidents, it would not be beneficial for them to relive the trauma each time they sit in a car.

Selective manipulation of memories

In lab experiments, Jun-Hyeong Cho, M.D., Ph.D., an assistant professor of molecular, cell, and systems biology, and Woong Bin Kim, his postdoctoral researcher, found that fear memory can be manipulated in such a way that some beneficial memories are retained while others, detrimental to our daily life, are suppressed. The research, done using a mouse model and published in Neuron, offers insights into how PTSD and specific phobias may be better treated.

“In the brain, neurons communicate with each other through synaptic connections, in which signals from one neuron are transmitted to another neuron by means of neurotransmitters,” explains research leader Cho. “We demonstrated that the formation of fear memory associated with a specific auditory cue involves selective strengthening in synaptic connections which convey the auditory signals to the amygdala, a brain area essential for fear learning and memory. We also demonstrated that selective weakening of the connections erased fear memory for the auditory cue.”

In the lab, mice were exposed to two sounds: a high-pitch tone and a low-pitch tone. Neither tone produced a fear response in the mice. Next, they paired the high-pitched tone with a mild footshock administered to the mice.  Again exposed to the tones, during the high-pitch version (without accompanying footshock), the mice responded by ceasing all movement, called freezing behavior.  They showed no such response to the low-pitch sound (with no accompanying footshock). The researchers found that such behavioral training strengthened synaptic connections that relay the high-pitch tone signals to the amygdala.

Optogenetics used to weaken synaptic connection

The researchers then used a method called optogenetics to weaken the synaptic connection with light, which erased the fear memory for the high-pitch tone. In the brain, neurons receiving the high- and low-pitch tone signals are intermingled,. The researchers were able, however, to experimentally stimulate just those neurons that responded to the high-pitch sound.

Cho: “Using low-frequency stimulations with light, we were able to erase the fear memory by artificially weakening the connections conveying the signals of the sensory cue – a high-pitch tone in our experiments – that are associated with the aversive event, namely, the footshock.”

The researcher stresses that for adaptive fear responses to be developed, the brain must discriminate between different sensory cues and associate only relevant stimuli with aversive events.

“This study expands our understanding of how adaptive fear memory for a relevant stimulus is encoded in the brain,” he said. “It is also applicable to developing a novel intervention to selectively suppress pathological fear while preserving adaptive fear in PTSD.”

The researchers note that their method can be adapted for other research, such as “reward learning” where stimulus is paired with reward. They plan next to study the mechanisms involved in reward learning which has implications in treating addictive behaviors.

This video explains the methods used to selectively erease memories that create fear responses

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